|Year : 2022 | Volume
| Issue : 3 | Page : 118-123
Childhood trauma, loneliness, and quality of life in adults with euthymic bipolar disorder
Karen Chein1, Yi- Ting Hsieh1, Huai- Hsuan Tseng2, I Hui Lee2, Yen Kuang Yang3, Po See Chen2
1 Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
2 Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
3 Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University; Department of Psychiatry, Tainan Hospital, Ministry of Health and Welfare, Tainan, Taiwan
|Date of Submission||19-May-2022|
|Date of Decision||22-Jul-2022|
|Date of Acceptance||25-Jul-2022|
|Date of Web Publication||28-Sep-2022|
M.D., Ph.D Po See Chen
No. 138, Sheng Li Road, North District, Tainan 704
Source of Support: None, Conflict of Interest: None
Background: Individuals with childhood trauma may experience loneliness throughout their lives, which can potentially aggravate mental and physical health conditions. Moreover, accumulating evidence suggests that associations exist between childhood trauma and certain features of bipolar disorder (BD), including cognitive dysfunction, severity, and clinical course. But, it remains unclear whether loneliness is associated with childhood trauma or quality of life in adult patients with BD. Methods: We recruited 83 patients with euthymic BD and 40 control participants from the psychiatric outpatient clinic at National Cheng Kung University Hospital. Their severity of mood symptoms was measured according to the Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS). All study participants completed the childhood trauma questionnaire (CTQ), World Health Organization Quality of Life (WHOQOL) Scale and University of California, Los Angeles Loneliness Scale. Results: Compared with controls, patients with euthymic BD had significantly higher scores of HDRS (p < 0.01), YMRS (p < 0.001), CTQ (p < 0.001), loneliness scores (p < 0.001), but significantly lower WHOQOL scores (p < 0.001). In patients with euthymic BD, a significantly positive correlation was found between loneliness and CTQ scores (p < 0.001) and a significantly negative correlation was present between loneliness and WHOQOL scores (p < 0.001). These correlations were also present in the control group (p < 0.05 and p < 0.001). Conclusion: Euthymic BD patients had stronger feelings of loneliness than controls overall. In both euthymic BD and control patients, loneliness was positively correlated with childhood trauma and negatively correlated with quality of life. These findings warrant further investigations to strengthen the findings of the causal relationship between childhood trauma and loneliness.
Keywords: childhood neglect, childhood trauma questionnaire, University of California, Los Angeles Loneliness Scale, World Health Organization Quality of Life-BREF
|How to cite this article:|
Chein K, Hsieh YT, Tseng HH, Lee I H, Yang YK, Chen PS. Childhood trauma, loneliness, and quality of life in adults with euthymic bipolar disorder. Taiwan J Psychiatry 2022;36:118-23
|How to cite this URL:|
Chein K, Hsieh YT, Tseng HH, Lee I H, Yang YK, Chen PS. Childhood trauma, loneliness, and quality of life in adults with euthymic bipolar disorder. Taiwan J Psychiatry [serial online] 2022 [cited 2023 Jan 28];36:118-23. Available from: http://www.e-tjp.org/text.asp?2022/36/3/118/357339
| Introduction|| |
The term “loneliness” refers to the subjective feeling that one's social relations are insufficient. Both loneliness and social isolation are associated with increased mortality,. Loneliness is also associated with psychiatric conditions, such as depression, anxiety, suicidal ideation, and psychosis. Similarly, loneliness is often present in patients who suffer from mood disorders, and in those with serious mental illness, loneliness has been shown to lead to less healthy behavior. One study has also been reported that patients with schizophrenia have higher loneliness scores than healthy controls and a systemic review showed that most studies have focused on the clinical effects of loneliness in patients with unipolar depression. Despite the breadth of literature on loneliness and mental health, only a few studies have addressed how the effects of loneliness in psychiatric patients as compared to those in healthy controls.
Regarding the factors that possibly contribute to feelings of loneliness, Hojat suggested that childhood relationship disruptions can lead to emotional dysfunction, fragility, anxiety, and fears of intimacy and rejection in adults. These obstacles to forming and maintaining attachment relationships may then be associated with experiences of loneliness. Not surprisingly, loneliness in the young adulthood is associated with early attachment disorders, i.e., childhood trauma. Nenov-Matt et al. reported that high levels of perceived loneliness in patients with persistent depressive disorder and borderline personality disorder are associated rejection sensitivity, which likely is resulted from a history of childhood emotional abuse and neglect. Wilkialis et al. published a narrative review in which they proposed that loneliness induces depression in adulthood through the reward system, and the further identified childhood adversity as a distal factor in the process. Aas et al. found that childhood trauma is a risk factor for clinical severity of patients with bipolar disorder (BD) and childhood trauma causes alterations of affect regulation, impulse control, and cognitive functioning decreases the ability to cope with later stressors. The lifetime effects of childhood trauma on BD susceptibility and severity are evident. But, few studies have yet examined the prevalence and effects of loneliness in BD or the association between loneliness and childhood trauma in a BD population.
The World Health Organization considers the quality of life (QoL) to be a person's perception of their position in life in the context of the culture and values in which they live and in relation to their goals, expectations, standards and concerns. Severe and moderate loneliness has been shown to reduce both physical and mental components of QoL in older adults. Childhood trauma, including subtypes of neglect, psychological maltreatment, physical maltreatment and sexual abuse, has also been repeatedly associated with QoL in children and adult survivors. In addition, the presence of psychiatric disease, such as BD, contributes to the adverse effects of childhood neglect and psychological maltreatment on QoL. Poorer QoL is routinely found in BD patients, whether they are in a euthymic state or a manic state. Despite this set of strong associations, the relationship between loneliness, childhood trauma, and QoL in patients with BD is not fully known.
In the present study, we intended to study the associations between childhood trauma, loneliness, and QoL in adult euthymic BD patients. We hypothesized (a) that higher childhood trauma scores would be associated with higher loneliness in BD patients, and (b) that higher loneliness would be associated with poorer QoL in the BD population. We also intended to study whether there is any indication that subtypes of childhood trauma may play a specific rôle in causing adulthood loneliness in patients with BD.
| Methods|| |
The institutional review board at National Cheng Kung University Hospital approved the research protocol (IRB protocol number = B-BR-107-032, and date of approved = August 20, 2018), with the stipulation that all participants signed written informed consent forms before the study. The study took from October 2015 to August 2020.
We recruited 83 euthymic BD patients (aged 19–64 years) from the psychiatric outpatient clinic at National Cheng Kung University Hospital, and 40 healthy controls (aged 20–64 years), enrolled from National Cheng Kung University or from the community using advertisement on the billboard or on the Internet after their eligibility diagnosis was assessed according to the Diagnostic and Statistical Manual of Mental Illness, 4th Edition (DSM-IV) in an interview with a therapist for euthymic BD patients. Symptom severity was assessed using the 17-item Hamilton Depression Rating Scale (HDRS) and the 11-item Young Mania Rating Scale (YMRS), and the euthymic state was defined as YMRS and HDRS scores that were both 7 or lower. We consecutively enrolled patients who were receiving mood-stabilizer treatment, including valproic acid (VPA) or lithium (n = 19, 15.4%), VPA + antipsychotics (n = 45, 36.6 %), antipsychotics (n = 15, 12.2 %), and other treatments (including SSRI or no medication use) (n = 4, [3.3 %]).
Euthymic BD patients were rejected if they met the following exclusion criteria (as identified by chart evaluation and self-reporting): (a) major surgical or physical illnesses (including chronic illnesses, heart disease, stroke, kidney dialysis, transplantation, etc.); (b) pregnant or lactating patients; (c) DSM-IV diagnosis of substance abuse within the last three months, and (d) organic mental disease, mental retardation or dementia.
World Health Organization Quality of Life-brief
The World Health Organization Quality of Life-brief (WHOQOL-BREF) Taiwan version was used to assess the overall and specific features of quality of life,,,. This test is a powerful psychometric tool that includes an overall index and covers four components: physiology, psychology, social relations between individuals, and the environment. Cronbach's α ranges from 0.70 to 0.77 for the four domains, and the retest confidence factor ranges from 0.76 to 0.80 at the domain level.
Childhood Trauma Questionnaire
The childhood trauma questionnaire (CTQ) addresses five subtypes of abuse and neglect: emotional abuse, physical abuse, sexual abuse, emotional neglect, and physical neglect. Each item is rated on a scale of 1–5, ranging from “never true when you were growing up” to “very often true when you were growing up.” Scores range from 5 to 25 for each category of negative childhood experiences. Higher scores reflect higher levels of negative trauma in childhood. We used a cutoff score of “no/minimal” to “low to moderate” to represent the presence and absence of childhood trauma for each subtype. CTQ results have shown trial-retest reliability between 0.79 and 0.86 above the four-month average, and internally consistent confidence coefficients ranging from 0.66 to 0.92 for all samples. Previously, Scher et al.. explored the factor structure and reliability of CTQs in a sample of men and women from an ethnically mixed community, and the results have shown an acceptable internal consistency throughout the measurement.
University of California, Los Angeles loneliness scale
The University of California, Los Angeles Loneliness Scale (version 3) is a tool designed to measure loneliness that is widely used and has high reliability and validity. The scale contains 20 items, and the Cronbach's α for this sample is 0.65. Participants rate how often they felt as described in the entry using a four-point Likert scale, from “never” to “often.” The loneliness classifications, low degree, moderate degree, moderately high degree, and high degree, have also been provided.
The Chi-squared test and two-sample Student's t-test were used to assess the differences in demographic characteristics between groups (euthymic BD patients vs. controls). A partial correlation analysis (controlling for years of education because the euthymic BD group had a lower level of education) was done to examine the relationship between the loneliness score, childhood trauma, and QoL in the euthymic BD and control groups.
The Statistical Package for the Social Sciences software version 20.0 for Windows (SPSS Inc., Chicago, Illinois, USA) was used for analyzing all the study variables. The difference between the groups was considered significant if p-value was smaller than 0.05 (two-tailed).
| Results|| |
Childhood trauma experience and loneliness between groups
The summary characteristics of the participants are presented [Table 1]. Patients with euthymic BD had significantly lower numbers of education years and QoL scores, but higher HDRS, YMRS, CTQ, and loneliness scores compared to the controls. These significant differences mostly remained when education years was controlled (data not shown). The prevalence of childhood trauma experiences was higher in euthymic BD patients than in the control group.
|Table 1: Demographic data, childhood trauma experiences, loneliness, and social support in patients with bipolar disorder and controls|
Click here to view
Correlation between loneliness and childhood trauma questionnaire between groups
Partial correlation tests showed positive associations between loneliness and CTQ sum scores in both patients with euthymic BD (r = 0.52, p < 0.001) and controls (r = 0.35, p < 0.05) [Table 2]. With regard to the CTQ subscales, emotional abuse, physical abuse, emotional neglect, and physical neglect were positively associated with loneliness in the euthymic BD group. However, only the emotional neglect subscale was positively correlated with loneliness in the control group. Most of correlations survived after Bonferroni correction (significant p = 0.05/6 = 0.0083).
|Table 2: Partial correlations between loneliness and childhood trauma questionnaire or World Health Organization quality of life scores in bipolar disorder patients and controls, controlling for education years|
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Correlation between loneliness and quality of life between groups
Pearson's correlation test showed negative correlations between loneliness scale and WHOQoL sum score in both euthymic BD patients (r = −0.69, p < 0.001) and controls (r = −0.51, p = 0.001). Loneliness was negatively correlated with all WHOQoL subscales (i.e., overall, physical, psychological, social, and environment) in the euthymic BD group. In the control group, loneliness was negatively correlated with the physical, psychological, and social, but not overall and environment subscales of the WHOQoL. Most of correlations survived after Bonferroni correction (significant p-value = 0.05/6 = 0.0083).
| Discussion|| |
To our knowledge, this is the first study to compare euthymic BD patients and controls in loneliness and to test the associations of loneliness with childhood trauma and QoL in both groups. Our findings suggested that loneliness scores were generally higher in euthymic BD patients than in controls. Furthermore, more severe childhood trauma was associated with higher loneliness scores in both euthymic BD and control groups. Finally, negative correlations were observed between loneliness and QoL in both euthymic BD and control groups.
As shown in [Table 1], we found that loneliness was significantly higher in patients with BD at a euthymic stage than controls (46.51 ± 11.43 vs. 37.25 ± 8.41). Similarly, Nenov-Matt et al. found higher levels of loneliness and rejection sensitivity in patients with persistent depressive disorder and borderline personality disorder. The authors further concluded that rejection sensitivity is likely to mediate the effects of emotional abuse and neglect on loneliness in the patients. In addition, state rejection sensitivity was shown to be increased in both bipolar depression and unipolar depression,. The potential role of rejection sensitivity in mediating the loneliness of patients with BD needs further investigation. Wilkialis et al. suggested that a mechanism of loneliness in adulthood depression, involves attachment style, genetics, resilience, the social network, and the reward system. A similar mechanism may exist in BD, as associations have been observed between personality difficulties, insecure attachment, and symptom load in BD patients. Notably, these factors have also been linked to childhood trauma.
In the social domain, patients with BD and those with unipolar depression may face similar challenges. Depression-associated mood symptoms interfere with a patient's ability to form meaningful interpersonal relationships, both during and between mood episodes. This point is emphasized by a review article that 30%−60% of individuals with BD do not regain full social function between mood episodes.
Social functioning of patients with BD has been linked to coping styles. Patients with BD have lower adaptive and higher maladaptive coping style scores than controls. One may speculate that childhood trauma may have impacts on attachment and coping style of BD patients, which then lead to social dysfunction and loneliness. In line with this hypothesis, our data [Table 1] showed that more severe childhood trauma was associated with significantly higher loneliness scale in BD with the control group (p < 0.001). Daruy-Filho et al. reported that an association of childhood maltreatment exists with poor coping strategies in patients with BD, which may have negative impacts on objective social support and subjective feelings of loneliness. Studies have shown that childhood trauma leads to individual indifference, possibly as a coping strategy for living in abusive families. In college students, childhood trauma increases loneliness through indifference, and recognition from a social group could act as a protective factor. Furthermore, childhood trauma has been found to be associated with loneliness in the general population. Shevlin et al. examined the relationship between childhood abuse, loneliness, and psychiatric disease. They found that loneliness mediates the association between childhood abuse and several adult psychiatric disorders, including depression. But, the influences of loneliness on BD remain unclear. In our study [Table 2], only the emotional neglect subscale of the CTQ was significantly associated with loneliness in both euthymic BD (p < 0.001) and control groups (p < 0.001). Musetti et al. conducted a study to investigate childhood emotional neglect and parent-related loneliness in high school students and found that childhood emotional neglect is associated with parent-related loneliness. Our results further support that emotional neglect plays an important role in loneliness in both controls and patients with BD. Russo et al. found that noted a history of emotional neglect in patients with BD is associated with lower ability to recognize anger on the emotion recognition task, although the results for Russo et al. could not be replicated using the Mayer–Salovey–Caruso Emotional Intelligence Test. Zhao et al. discovered that emotional negligence is positively associated with adolescent depressive symptoms. In the same study, quality of friendship is found not only to be negatively associated with adolescent depressive symptoms but also alleviated the negative effects of emotional negligence on depressive symptoms in girls from immigrant families. Those results imply that social support, especially from peers, is a protective factor and a possible target of intervention. Those results also hinted that childhood trauma and loneliness have a significant impact on mood symptoms of patients with BD. We should note the relationship between childhood trauma and loneliness when treating patients with BD.
Sayegh et al. conducted a nonrandomized, single-arm prospective pilot study on the use of a group cognitive behavioral analysis system of psychotherapy (CBASP) for patients with BD. They found that this form of therapy can improve depressive symptoms and in social functioning of BD patients. The authors concluded that BD patients in depression episodes are likely to benefit from the 20-week group CBASP model.
As we predicted, our data [Table 2] showed that higher loneliness scale was significantly correlated with poorer QoL in euthymic BD (p < 0.001), and this significant association was also seen in the control group (p < 0.001). Several articles have reported a negative correlation between loneliness scale and QoL in community-dwelling older people,. Indeed, social support influences QoL through reducing loneliness and thus is an effective target for intervention. When interpersonal interactions have been increased (e.g., by the use of smartphones), loneliness scores are decreased and QoL is increased in an elderly cohort. Warren et al. investigated the influence of social support on psychological distress in adults with BD and have found lower perceived social support in the BD group. Poor social support is associated with psychological distress, but reassurance of worth and social integration is a protective factors. In their review on interventions for reducing loneliness, Veronese et al. highlighted three main interventions (i.e., meditation/ mindfulness, social cognitive training, and social support) can reduce in loneliness.
The main strength of this study is that we used a euthymic BD group and also included a control group. But, the readers are warned against over-interpret the study results because the study has five limitations:
- Causal relationships were unclear due to the cross-sectional study design.
- The sample size of this study was small. The potential mediating role of loneliness in the effects of childhood trauma on BD or QoL could not be tested. Future work on this topic should involve larger sample sizes and longitudinal study design.
- The mechanisms of increased loneliness in patients with BD remain ambiguous because we did not collect related psychological measures, such as attachment style and personality structure. We also did not make related biological measurements, such as functional connectivity or genetic factors. Future studies including these measures are warranted, to clarify the mechanisms underlying the associations.
- The current mood status of patients might be bias in the questionnaire scores, but was not re-verified in this study.
- The recall of traumatic experience might also be biased by the memory distortion for traumatic event.
Euthymic BD patients had overall stronger feelings of loneliness than controls. In both the euthymic BD and control groups, loneliness was positively correlated with childhood trauma and negatively correlated with QoL. The causal relationship between childhood trauma and loneliness should therefore be further investigated.
| Acknowledgments|| |
The authors thank study participants and also thank Chien-Ting Lin for his administrative support.
| Financial Support and Sponsorship|| |
This work was financially supported by the Ministry of Science and Technology, Taiwan (MOST 104-2321-B-006-031, MOST 106-2410-H-468-012-MY2, MOST 107-2314-B-006-082, MOST 107-2628-B-006-005, MOST 108-2320-B-006-004, MOST 108-2410-H-468-009, MOST 109-2628-B-006-004, and MOST 110-2314-B-006-061-MY3) and National Cheng Kung University Hospital (NCKUH-10704010 and NCKUH-10902014).
| Conflicts of Interest|| |
The authors declare no conflicts of interest in relation to this work. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
| References|| |
Peplau LA, Perlman D: Loneliness: A Sourcebook of Current Theory, Research and Therapy
. New York: Wiley, 1982.
Xia N, Li H: Loneliness, social isolation, and cardiovascular health. Antioxid Redox Signal
2018; 28: 837-51.
Holt-Lunstad J, Smith TB, Baker M, et al.: Loneliness and social isolation as risk factors for mortality: a meta-analytic review. Perspect Psychol Sci
2015; 10: 227-37.
Beutel ME, Klein EM, Brähler E, et al.: Loneliness in the general population: Prevalence, determinants and relations to mental health. BMC Psychiatry
2017; 17: 97.
Narita Z, Stickley A, DeVylder J: Loneliness and psychotic experiences in a general population sample. Schizophr Res
2020; 218: 146-50.
Fortuna KL, Ferron J, Bianco CL, et al.: Loneliness and its association with health behaviors in people with a lived experience of a serious mental illness. Psychiatr Q
2021; 92: 101-6.
Eglit GM, Palmer BW, Martin AS, et al.: Loneliness in schizophrenia: Construct clarification, measurement, and clinical relevance. PLoS One
2018; 13: e0194021.
Wang J, Mann F, Lloyd-Evans B, et al.: Associations between loneliness and perceived social support and outcomes of mental health problems: A systematic review. BMC Psychiatry
2018; 18: 156.
Hojat M: A psychodynamic view of loneliness and mother-child relationships: a review of theoretical perspectives and empirical findings. J Soc Behav Pers
1987; 2: 89-104.
Hecht DT, Baum SK: Loneliness and attachment patterns in young adults. J Clin Psychol
1984; 40: 193-7.
Nenov-Matt T, Barton BB, Dewald-Kaufmann J, et al.: Loneliness, social isolation and their difference: a cross-diagnostic study in persistent depressive disorder and borderline personality disorder. Front Psychiatry
2020; 11: 608476.
Wilkialis L, Rodrigues N, Majeed A, et al.: Loneliness-based impaired reward system pathway: theoretical and clinical analysis and application. Psychiatry Res
2021; 298: 113800.
Aas M, Henry C, Andreassen OA, et al.: The role of childhood trauma in bipolar disorders. Int J Bipolar Disord
2016; 4: 2.
Fisher HL, Hosang GM: Childhood maltreatment and bipolar disorder: a critical review of the evidence. Mind Brain J Psychiatry
2010; 1: 75-85.
World Health Organization: WHOQOL: Measuring Quality of Life.
Geneva, Switzerland: World Health Organization, 1998.
Musich S, Wang SS, Hawkins K, et al.: The impact of loneliness on quality of life and patient satisfaction among older, sicker adults. Gerontol Geriatr Med
2015; 1: 2333721415582119.
Weber S, Jud A, Landolt MA: Quality of life in maltreated children and adult survivors of child maltreatment: a systematic review. Qual Life Res
2016; 25: 237-55.
Pascual-Sánchez A, Jenaro C, Montes-Rodríguez JM: Quality of life in euthymic bipolar patients: a systematic review and meta-analysis. J Affect Disord
2019; 255: 105-15.
Gazalle FK, Hallal PC, Andreazza AC, et al.: Manic symptoms and quality of life in bipolar disorder. Psychiatry Res
2007; 153: 33-8.
Jang Y, Hsieh CL, Wang YH, et al.: A validity study of the WHOQOL-BREF assessment in persons with traumatic spinal cord injury. Arch Phys Med Rehabil
2004; 85: 1890-5.
Yang SC, Kuo PW, Wang JD, et al.: Quality of life and its determinants of hemodialysis patients in Taiwan measured with WHOQOL-BREF(TW). Am J Kidney Dis
Yao G, Wu CH: Factorial invariance of the WHOQOL-BREF among disease groups. Qual Life Res
2005; 14: 1881-8.
Yao G, Chung CW, Yu CF, et al.: Development and verification of validity and reliability of the WHOQOL-BREF Taiwan version. J Formos Med Assoc
2002; 101: 342-51.
Bernstein DP, Ahluvalia T, Pogge D, et al.: Validity of the Childhood Trauma Questionnaire in an adolescent psychiatric population. J Am Acad Child Adolesc Psychiatry
1997; 36: 340-8.
Scher CD, Stein MB, Asmundson GJ, et al.: The childhood trauma questionnaire in a community sample: Psychometric properties and normative data. J Trauma Stress
2001; 14: 843-57.
Russell DW: UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. J Pers Assess
1996; 66: 20-40.
Yildirim Y, Kocabiyik S: The relationship between social support and loneliness in Turkish patients with cancer. J Clin Nurs
2010; 19: 832-9.
Ehnvall A, Mitchell PB, Hadzi-Pavlovic D, et al.: Rejection sensitivity and pain in bipolar versus unipolar depression. Bipolar Disord
2014; 16: 190-8.
Ehnvall A, Mitchell PB, Hadzi-Pavlovic D, et al.: Pain and rejection sensitivity in bipolar depression. Bipolar Disord
2011; 13: 59-66.
Wagner-Skacel J, Bengesser S, Dalkner N, et al.: Personality structure and attachment in bipolar disorder. Front Psychiatry
2020; 11: 410.
Citak C, Erten E: Impact of childhood trauma and attachment on resilience in remitted patients with bipolar disorder. J Affect Disord
2021; 280: 219-27.
Furukawa TA, Azuma H, Takeuchi H, et al.: 10-year course of social adjustment in major depression. Int J Soc Psychiatry
2011; 57: 501-8.
MacQueen GM, Young LT, Joffe RT: A review of psychosocial outcome in patients with bipolar disorder. Acta Psychiatr Scand
2001; 103: 163-70.
Karaş H, Çarpar E, Küçükgöncü S, et al.: Associations of attachment and coping styles with social functioning in patients with bipolar disorder I. J Nerv Ment Dis
2021; 209: 578-84.
Daruy-Filho L, Brietzke E, Kluwe-Schiavon B, et al.: Childhood maltreatment and coping in bipolar disorder. Psychol Neurosci
2013; 6: 271-7.
Fang J, Wang X, Yuan KH, et al.: Childhood psychological maltreatment and moral disengagement: A moderated mediation model of callous-unemotional traits and empathy. Pers Individ Dif
2020; 157: 109814.
Wang Y, Warmenhoven H, Feng Y, et al.: The relationship between childhood trauma and suicidal ideation, the mediating role of identification of all humanity, indifference and loneliness. J Affect Disord
2022; 299: 658-65.
Hyland P, Shevlin M, Cloitre M, et al.: Quality not quantity: Loneliness subtypes, psychological trauma, and mental health in the US adult population. Soc Psychiatry Psychiatr Epidemiol
2019; 54: 1089-99.
Shevlin M, McElroy E, Murphy J: Loneliness mediates the relationship between childhood trauma and adult psychopathology: evidence from the adult psychiatric morbidity survey. Soc Psychiatry Psychiatr Epidemiol
2015; 50: 591-601.
Musetti A, Grazia V, Manari T, et al.: Linking childhood emotional neglect to adolescents' parent-related loneliness: self-other differentiation and emotional detachment from parents as mediators. Child Abuse Negl
2021; 122: 105338.
Russo M, Mahon K, Shanahan M, et al.: The association between childhood trauma and facial emotion recognition in adults with bipolar disorder. Psychiatry Res
2015; 229: 771-6.
Rokita KI, Dauvermann MR, Donohoe G: Early life experiences and social cognition in major psychiatric disorders: a systematic review. Eur Psychiatry
2018; 53: 123-33.
Zhao J, Sun X, Wang Q: Emotional neglect and depressive symptoms of left-behind adolescents: the role of friendship quality and gender. J Affect Disord
2021; 295: 377-83.
Sayegh L, Touré EH, Farquhar E, et al.: Group cognitive behavioral analysis system of psychotherapy (CBASP): a pilot study for bipolar depression. Front Psychiatry
2020; 11: 565681.
Beridze G, Ayala A, Ribeiro O, et al.: Are loneliness and social isolation associated with quality of life in older adults? Insights from Northern and Southern Europe. Int J Environ Res Public Health
2020; 17: 8637.
Tan SS, Fierloos IN, Zhang X, et al.: The association between loneliness and health related quality of life (HR-QoL) among community-dwelling older citizens. Int J Environ Res Public Health
2020; 17: 600.
Tsai HH, Cheng CY, Shieh WY, et al.: Effects of a smartphone-based videoconferencing program for older nursing home residents on depression, loneliness, and quality of life: a quasi-experimental study. BMC Geriatr
2020; 20: 27.
Warren CD, Fowler K, Speed D, et al.: The influence of social support on psychological distress in Canadian adults with bipolar disorder. Soc Psychiatry Psychiatr Epidemiol
2018; 53: 815-21.
Veronese N, Galvano D, D'Antiga F, et al.: Interventions for reducing loneliness: an umbrella review of intervention studies. Health Soc Care Community
2021; 29: e89-96.
[Table 1], [Table 2]